This book contains all syllabus for life science CSIR NET
1. MOLECULES AND THEIR INTERACTION RELAVENT TO BIOLOGY
A. Structure of atoms, molecules and chemical bonds.
B Composition, structure and function of biomolecules (carbohydrates, lipids,
proteins, nucleic acids and vitamins).
C. Stablizing interactions (Van der Waals, electrostatic, hydrogen bonding, hydrophobic
D Principles of biophysical chemistry (pH, buffer, reaction kinetics, thermodynamics,
E. Bioenergetics, glycolysis, oxidative phosphorylation, coupled reaction, group
transfer, biological energy transducers.
F. Principles of catalysis, enzymes and enzyme kinetics, enzyme regulation, mechanism of
enzyme catalysis, isozymes
G. Conformation of proteins (Ramachandran plot, secondary structure, domains, motif
H. Conformation of nucleic acids (helix (A, B, Z), t-RNA, micro-RNA).
I. Stability of proteins and nucleic acids.
J. Metabolism of carbohydrates, lipids, amino acids nucleotides and vitamins.
2. CELLULAR ORGANIZATION
A) Membrane structure and function
(Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis,
ion channels, active transport, membrane pumps, mechanism of sorting and regulation
of intracellular transport,electrical properties of membranes).
B) Structural organization and function of intracellular organelles (Cell wall, nucleus,
mitochondria, Golgi bodies, lysosomes, endoplasmic reticulum, peroxisomes, plastids,
vacuoles, chloroplast, structure & function of cytoskeleton and its role in motility).
C) Organization of genes and chromosomes (Operon, unique and repetitive DNA,
interrupted genes, gene families, structure of chromatin and chromosomes,
heterochromatin, euchromatin, transposons).
D) Cell division and cell cycle (Mitosis and meiosis, their regulation, steps in cell cycle,
regulation and control of cell cycle).
E) Microbial Physiology (Growth yield and characteristics, strategies of cell division,
3. FUNDAMENTAL PROCESSES
A) DNA replication, repair and recombination (Unit of replication, enzymes involved,
replication origin and replication fork, fidelity of replication, extrachromosomal replicons,
DNA damage and repair mechanisms, homologous and site-specific recombination).
B) RNA synthesis and processing (transcription factors and machinery, formation of
initiation complex, transcription activator and repressor, RNA polymerases, capping,